The main objective of this WP is to develop or adapt existing in silico methods for endocrine disruptor compounds. WP4 will develop QSAR and PK/PBPK models in support of the evaluation and integration of the data streams of the project. QSAR can provide pertinent and reliable information about ED potential based on structural information (physicochemical properties of the compounds). Output will be provided to WP5 for integration in hazard and risk decision schemes.