WP5 will use a systems biology pipeline to propose an integrative testing strategy (ITS) for EDs testing. WP5 aims 1) at integrating existing knowledge and data generated during the project from WP2 (in vivo models), WP3 (in vitro models) and WP4 (in silico models) in order to interpret the WP1 data and make new hypothesis; 2) at providing the tools and computational models for the elucidation of the mechanistic understanding of the links between different levels of biological organization and response, from gene expression to phenotypic response going through proteome and metabolome perturbations related to ED exposure. As a result, existing AOPs will be further advanced and new ones will be developed.